Kappes U P, Göritz N, Wigger-Alberti W, Heinemann C, Elsner P
Department of Dermatology, Friedrich-Schiller-University, Jena, Germany.
Acta Derm Venereol. 2001 Nov-Dec;81(6):403-5. doi: 10.1080/000155501317208327.
Irritant contact dermatitis has a broad spectrum of clinical features and is a leading cause of occupational disease worldwide. It has been shown previously that a combination of chemically different irritants may cause an additive effect compared to single application of these substances. In this study, tandem application of sodium lauryl sulfate and n-propanol was investigated in 20 human volunteers using non-invasive bioengineering methods, such as measurement of transepidermal water loss and chromametry. N-propanol did not enhance cumulative skin irritation when used with sodium lauryl sulfate, as has been reported for toluene. As n-propanol is the active ingredient in many disinfectants, this is of particular interest regarding occupational skin irritation in health care workers.
刺激性接触性皮炎具有广泛的临床特征，是全球职业病的主要原因。先前已经表明，与单独使用这些物质相比，化学性质不同的刺激物组合可能会产生相加效应。在本研究中，使用非侵入性生物工程方法，如经表皮水分流失测量和色度测量，对20名人类志愿者进行了月桂醇硫酸酯钠和正丙醇串联应用的研究。与甲苯的情况一样，正丙醇与月桂醇硫酸酯钠一起使用时不会增强累积皮肤刺激性。由于正丙醇是许多消毒剂的活性成分，这对于医护人员的职业性皮肤刺激尤其重要。
