三例伴有16号染色体臂间倒位的骨髓增生异常综合征
Three cases of the myelodysplastic syndrome with pericentric inversion of chromosome 16.
作者信息
Narayanan M N, Geary C G, Harrison C J, Cinkotai K I, Lewis M J
机构信息
Department of Haematology, Manchester Royal Infirmary.
出版信息
Br J Haematol. 1993 Sep;85(1):217-9. doi: 10.1111/j.1365-2141.1993.tb08677.x.
Inversion of chromosome 16, inv(16)(p13q22), is characteristic of acute myeloid leukaemia (AML) with eosinophilia and is rarely found in the myelodysplastic syndrome (MDS). We report three cases of MDS in which inv(16) was observed. They were classified to FAB subtypes RA, RARS and RAEBT; eosinophilia or abnormal eosinophils were not observed. The disease appeared to be stable in all three patients. MDS with inv(16) without eosinophilia may be a rare subgroup associated with a good prognosis.
16号染色体倒位，inv(16)(p13q22)，是伴有嗜酸性粒细胞增多的急性髓系白血病（AML）的特征，在骨髓增生异常综合征（MDS）中很少见。我们报告了3例观察到inv(16)的MDS病例。它们被分类为FAB亚型RA、RARS和RAEBT；未观察到嗜酸性粒细胞增多或异常嗜酸性粒细胞。这三例患者的病情似乎都很稳定。无嗜酸性粒细胞增多的inv(16) MDS可能是一个预后良好的罕见亚组。
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