Park K G, Blessing K, McLaren K M, Watson A C
Department of Surgery, Aberdeen University, Scotland.
Br J Plast Surg. 1993 Oct;46(7):607-10. doi: 10.1016/0007-1226(93)90115-r.
555 cases of malignant melanoma less than 1.5 mm in depth were studied. 30 recurred locally or metastasised during follow-up. The width and depth of excision was similar in those with and without recurrence. There were no local recurrences in tumours < 1.0 mm which had been completely excised, irrespective of the width of excision. Other variables, the size of the primary tumour (p < 0.03), the depth of uninvolved dermis deep to the lesion (p < 0.01), the Clark level (p < 0.03) and the presence of lesional regression (p < 0.001), identify a sub-group of thin melanomas which have a poor prognosis irrespective of local treatment.
对555例深度小于1.5毫米的恶性黑色素瘤进行了研究。30例在随访期间出现局部复发或转移。复发组和未复发组的切除宽度和深度相似。肿瘤深度<1.0毫米且已完全切除的患者，无论切除宽度如何，均无局部复发。其他变量，如原发肿瘤大小（p<0.03）、病变下方未受累真皮的深度（p<0.01）、克拉克分级（p<0.03）和病变消退的存在情况（p<0.001），确定了一组薄型黑色素瘤亚组，无论局部治疗如何，其预后均较差。
