Harris I R, Bottomley W, Wood E J, Cunliffe W J
Department of Biochemistry and Molecular Biology, University of Leeds, UK.
Clin Exp Dermatol. 1993 Sep;18(5):417-20. doi: 10.1111/j.1365-2230.1993.tb02240.x.
Human keratinocytes obtained from seven elderly patients who had long-standing leg ulcers of venous or rheumatoid origin were grown into sheets for autografting on to their ulcers on at least one and, in some cases, two occasions. Following the application of the autografts on to the ulcers the appearance of the ulcer base improved with an increase in the vascularity of the granulation tissue and decrease in the amount of exudate. An 'edge effect' was also noted in five cases, with the previously indolent-looking edge of the ulcer appearing healthier and more active. However, over a 4-month follow-up period there was no complete re-epithelialization in any of the ulcers despite these initial improvements.
从七名患有长期静脉性或类风湿性腿部溃疡的老年患者身上获取的人角质形成细胞，被培养成薄片，至少在一次，某些情况下是两次，用于自体移植到他们的溃疡处。将自体移植物应用于溃疡后，溃疡底部的外观有所改善，肉芽组织的血管增多，渗出物减少。在五例病例中还观察到“边缘效应”，溃疡先前看似不活跃的边缘显得更健康、更活跃。然而，在4个月的随访期内，尽管有这些初步改善，任何溃疡都没有完全重新上皮化。
