Beele H, Naeyaert J M, Goeteyn M, De Mil M, Kint A
Department of Dermatology, University Hospital of Gent, Belgium.
Dermatologica. 1991;183(1):31-5. doi: 10.1159/000247628.
Twelve patients with 16 leg ulcers, existing for at least 3 months and not responsive to conventional inpatient therapy of at least 3 weeks, were treated with repeated applications of cultured allogenic keratinocyte sheets. A marked decrease in size was seen in all ulcers but 2. Complete closure of the ulcer was seen in 62% of the ulcers within 8 weeks. Healing was due to enhanced granulation and increased epithelialization, starting from the periphery of the wound. This edge effect suggests that the epidermal allografts act by stimulation of migration and/or multiplication of the acceptor's keratinocytes, rather than by take of the allograft.
12例患者共16处腿部溃疡，病程至少3个月，对至少3周的传统住院治疗无反应，接受了培养的同种异体角质形成细胞片的反复应用治疗。除2处溃疡外，所有溃疡面积均显著减小。62%的溃疡在8周内完全愈合。愈合是由于肉芽组织增生增强和上皮化增加，从伤口边缘开始。这种边缘效应表明，表皮同种异体移植通过刺激受体角质形成细胞的迁移和/或增殖起作用，而不是通过同种异体移植的存活。
