Vázquez-Doval F J, Ruiz de Erenchun F, Páramo J A, Quintanilla E
Department of Dermatology, University Clinic of Navarra, University of Navarra, Pamplona, Spain.
Clin Exp Dermatol. 1993 Sep;18(5):441-4. doi: 10.1111/j.1365-2230.1993.tb02246.x.
Malignant atrophic papulosis is a systemic vaso-occlusive disorder characterized by typical skin lesions. We report two new cases with impairment of blood fibrinolytic activity and alterations in platelet function. The first case showed an increase in plasminogen activator inhibitor-1 (PAI-1) activity, and the second case had a decrease in platelet aggregation induced by adenosine diphosphate and adrenaline but normal with collagen. The impairment of blood fibrinolytic activity and platelet aggregation may have pathogenic and therapeutic implications in malignant atrophic papulosis.
恶性萎缩性丘疹病是一种以典型皮肤损害为特征的系统性血管闭塞性疾病。我们报告了两例血液纤溶活性受损及血小板功能改变的新病例。第一例显示纤溶酶原激活物抑制剂-1（PAI-1）活性增加，第二例由二磷酸腺苷和肾上腺素诱导的血小板聚集减少，但对胶原的反应正常。血液纤溶活性和血小板聚集的受损可能对恶性萎缩性丘疹病的发病机制和治疗具有重要意义。
