Nagasawa H, Furuichi R, Sakamoto S, Yamamoto K
Experimental Animal Research Laboratory, Meiji University, Kanagawa, Japan.
Jikken Dobutsu. 1993 Oct;42(4):631-4. doi: 10.1538/expanim1978.42.4_631.
Spontaneous mammary tumour potential was compared between virgins and breeders of a high mammary tumour strain of SHN mice. Virgins were essentially similar to breeders in both the cumulative and the monthly incidences of mammary tumours. DNA synthesizing enzyme activities and the number and the weight of mammary tumours also differed little between groups. While the number of preneoplastic mammary hyperplastic alveolar nodules (HAN) was significantly higher in breeders than in virgins, little difference was observed between groups in the end-bud formation and the duct growth of normal glands and the growth of HAN. These results indicate that in SHN mice virgins have similar mammary tumour potential to breeders, which is much advantageous for practical use of this strain as an animal model for human breast and other types of cancers.
对SHN小鼠高乳腺肿瘤品系的处女鼠和繁殖鼠的自发乳腺肿瘤潜能进行了比较。处女鼠在乳腺肿瘤的累积发病率和月发病率方面与繁殖鼠基本相似。两组之间的DNA合成酶活性以及乳腺肿瘤的数量和重量也差异不大。虽然繁殖鼠中癌前乳腺增生性肺泡结节（HAN）的数量显著高于处女鼠，但在正常腺体的终末芽形成、导管生长以及HAN的生长方面，两组之间观察到的差异很小。这些结果表明，在SHN小鼠中，处女鼠具有与繁殖鼠相似的乳腺肿瘤潜能，这对于将该品系作为人类乳腺癌和其他类型癌症的动物模型进行实际应用非常有利。
