中药对小鼠乳腺肿瘤中DNA合成酶活性的影响。
Effects of Chinese herbal medicines on DNA-synthesizing enzyme activities in mammary tumors of mice.
作者信息
Sakamoto S, Furuichi R, Matsuda M, Kudo H, Suzuki S, Sugiura Y, Kuwa K, Tajima M, Matsubara M, Namiki H
机构信息
Medical Research Institute, Tokyo Medical and Dental University, Japan.
出版信息
Am J Chin Med. 1994;22(1):43-50. doi: 10.1142/S0192415X94000061.
Sho-saiko-to (SST) and Juzen-taiho-to (JTT), Japanese modified Chinese herbal prescriptions, suppressed the activities of thymidylate synthetase and thymidine kinase involved in de novo and salvage pathways for pyrimidine nucleotide synthesis, respectively, in mammary tumors of SHN mice with the reduction of serum prolactin level. These results indicate that SST and JTT may have the antitumor effects on mammary tumors.
小柴胡汤（SST）和十全大补汤（JTT）是日本改良的中药方剂，它们分别抑制了SHN小鼠乳腺肿瘤中参与嘧啶核苷酸合成的从头合成途径和补救途径的胸苷酸合成酶和胸苷激酶的活性，同时血清催乳素水平降低。这些结果表明，小柴胡汤和十全大补汤可能对乳腺肿瘤具有抗肿瘤作用。
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