Colaco M P, Desai M P, Choksi C S, Shah K N, Mehta R U
Division of Pediatric Endocrinology, Bai Jerbai Wadia Hospital for Children, Bombay.
Indian J Pediatr. 1993 May-Jun;60(3):445-50. doi: 10.1007/BF02751212.
Ten children, five boys and five girls with true precocious puberty at an early age were found to have hypothalamic hamartomas on brain imaging. Very early onset of puberty, varying from a few weeks to three years of age, and rapid progression were characteristic. Accelerated growth velocity and markedly advanced bone age were evident in all. Gonadotropin and gonadal hormone levels were elevated above the prepubertal range. Six children had associated developmental delay or hyperactivity.
在脑部影像学检查中发现，10名儿童（5名男孩和5名女孩）患有早期真性性早熟，伴有下丘脑错构瘤。其特征为青春期极早开始，发病年龄从几周至3岁不等，且进展迅速。所有患儿均有生长速度加快和骨龄明显提前的表现。促性腺激素和性腺激素水平高于青春期前范围。6名儿童伴有发育迟缓或多动症状。
