Alvarez J O, Caceda J, Woolley T W, Carley K W, Baiocchi N, Caravedo L, Navia J M
Department of Public Health, University of Alabama at Birmingham.
J Dent Res. 1993 Dec;72(12):1573-6. doi: 10.1177/00220345930720120701.
A prospective, four-year longitudinal study of 209 Peruvian children was conducted to evaluate the effect of a single malnutrition episode occurring at infancy (i.e., < 1 year of age) on dental caries in the primary teeth. Children were recruited into the study at age 6-11 months after they had suffered from a malnutrition episode and were thus classified by anthropometry as either: (1) Normal; (2) Wasted (low weight for height); (3) Stunted (low height for age); or (4) Stunted and Wasted (S and W). Eruption of the primary teeth was significantly delayed in all malnourished children; however, the effect of stunting--that is, retarded linear growth--was more pronounced and lasted longer than that of wasting or acute malnutrition (i.e., 2.5 vs. 1.5 years, respectively). By age 4 years, children from group 4 (S and W) showed a significantly higher caries experience in the primary teeth than did those in any of the other three groups. In summary, this longitudinal study has confirmed previous studies in animals and indirect epidemiological evidence which had suggested a cause-effect relationship between early malnutrition and increased dental caries.
对209名秘鲁儿童进行了一项为期四年的前瞻性纵向研究，以评估婴儿期（即小于1岁）发生的单次营养不良事件对乳牙龋齿的影响。这些儿童在6至11个月大时经历了一次营养不良事件后被纳入研究，并根据人体测量学分为以下几类：（1）正常；（2）消瘦（身高体重比低）；（3）发育迟缓（年龄别身高低）；或（4）发育迟缓和消瘦（S和W）。所有营养不良儿童的乳牙萌出均显著延迟；然而，发育迟缓（即线性生长迟缓）的影响比消瘦或急性营养不良更为明显且持续时间更长（分别为2.5年和1.5年）。到4岁时，第4组（S和W）的儿童乳牙龋齿发生率显著高于其他三组中的任何一组。总之，这项纵向研究证实了先前在动物身上的研究以及间接流行病学证据，这些研究表明早期营养不良与龋齿增加之间存在因果关系。
