Lacquaniti L G, Irone M, Barbacini S, Merlo F, Demo P, Pellegrin C, Dan M
2nd Department of ICU, Hospital S. Bortolo, Vicenza, Italy.
Int J Clin Monit Comput. 1993 Oct;10(3):181-5. doi: 10.1007/BF01246453.
Severe brain damage may cause alterations of cardiovascular function: heart rate, particularly, require the integrity of the vagal, sympathetic and central nervous systems. We studied brain-heart functional relation and neurovegetative modulation by spectral analysis of heart rate variability (HRV). This technique allows separate evaluation of the sympathetic and vagal components of heart rate modulation. In order to correlate changes in HRV with brain damage, we performed 45 recordings in 6 patients (5/1 M/F) by means of autoregressive analysis (AAR). All patients were admitted to the ICU for severe brain damage (anoxic, traumatic or vascular). In 4 patients clinical outcome was brain death, in 2 permanent vegetative status. Two different patterns were found: one in patients with brain death, the other in patients with vegetative status. The small number of patients does not allow definitive conclusions from collected data, but that application of spectral analysis of HRV seems to be a useful monitoring of brain damage subjects.
特别是心率，需要迷走神经、交感神经和中枢神经系统的完整性。我们通过心率变异性（HRV）频谱分析研究了脑-心功能关系和神经植物调节。该技术允许分别评估心率调节的交感神经和迷走神经成分。为了将HRV变化与脑损伤相关联，我们通过自回归分析（AAR）对6例患者（5例男性/1例女性）进行了45次记录。所有患者因严重脑损伤（缺氧性、创伤性或血管性）入住重症监护病房。4例患者临床结局为脑死亡，2例为永久性植物状态。发现了两种不同模式：一种在脑死亡患者中，另一种在植物状态患者中。患者数量较少，无法从收集的数据中得出明确结论，但HRV频谱分析的应用似乎是对脑损伤患者进行有用监测的方法。
