Cucinotta V, Mangano A, Nobile G, Santoro A M, Vecchio G
Dipartimento di Scienze Chimiche, Università di Catania, Italy.
J Inorg Biochem. 1993 Nov 15;52(3):183-90. doi: 10.1016/0162-0134(93)80039-c.
The new platinum(II) complexes of beta-cyclodextrin functionalized at the primary position with ethylenediamine or with propylenediamine were synthesized and characterized by mass spectrometry, electronic spectrophotometry, and multinuclear NMR spectroscopy. Platinum(II) complexation makes the cavity more asymmetric. These complexes were tested in vitro for their cytotoxic activity. The relevance of the low activity observed regarding the interaction between the cell and the cyclodextrin cavity is discussed.
