从艾氏海绵属的一种海洋海绵中分离并阐明内皮素A受体抑制剂34-硫酸化bastadin 13的结构。
Isolation and structure elucidation of 34-sulfatobastadin 13, an inhibitor of the endothelin A receptor, from a marine sponge of the genus Ianthella.
作者信息
Gulavita N K, Wright A E, McCarthy P J, Pomponi S A, Kelly-Borges M, Chin M, Sills M A
机构信息
Harbor Branch Oceanographic Institution, Inc., Ft. Pierce, Florida 34946.
出版信息
J Nat Prod. 1993 Sep;56(9):1613-7. doi: 10.1021/np50099a026.
PMID:8254355
Abstract
34-Sulfatobastadin 13 [1] was isolated from the sponge Ianthella sp. Its structure was elucidated by nmr techniques and chemical transformation to bastadin 13 [2]. Compound 1 weakly inhibited binding to the endothelin A receptor (ETA), while compound 2 inhibited growth of Bacillus subtilis.
摘要
34-硫酸化bastadin 13 [1]是从海绵Ianthella sp.中分离得到的。其结构通过核磁共振技术以及化学转化为bastadin 13 [2]得以阐明。化合物1对内皮素A受体（ETA）的结合有微弱抑制作用，而化合物2则抑制枯草芽孢杆菌的生长。
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