大鼠出生后脑发育过程中血脑脊髓液屏障交换减少的性质。
The nature of the decrease in blood-cerebrospinal fluid barrier exchange during postnatal brain development in the rat.
作者信息
Habgood M D, Knott G W, Dziegielewska K M, Saunders N R
机构信息
Clinical Neurological Sciences (Developmental) Group, Faculty of Medical Sciences, Southampton General Hospital.
出版信息
J Physiol. 1993 Aug;468:73-83. doi: 10.1113/jphysiol.1993.sp019760.
Abstract
- The blood-cerebrospinal fluid (CSF) exchange of a wide range of passively transported lipid insoluble compounds (0.43-5.4 nm molecular radius) has been investigated in rats at different stages of postnatal development (2 days old to adult). A novel 'litter-based' model for investigating blood-CSF barrier exchange in immature animals is described. 2. At each age investigated there was a clear inverse correlation between molecular radius and blood-CSF barrier exchange, in addition to an overall decrease in blood-CSF barrier exchange with increasing age. 3. The decrease in blood-CSF barrier exchange with age was not consistent with a reduction in pore diameters, nor does it appear to be due to an increase in the CSF sink effect with age. It seems likely to be due to a relative decrease in the number of a population of large diameter pores.
摘要
- 研究了一系列被动转运的脂溶性不溶性化合物（分子半径为0.43 - 5.4纳米）在大鼠出生后不同发育阶段（2日龄至成年）的血脑脊液（CSF）交换情况。描述了一种用于研究未成熟动物血脑脊液屏障交换的新型“基于窝仔”模型。2. 在每个研究年龄，除了随着年龄增长血脑脊液屏障交换总体下降外，分子半径与血脑脊液屏障交换之间存在明显的负相关。3. 血脑脊液屏障交换随年龄的下降与孔径减小不一致，似乎也不是由于随着年龄增长脑脊液汇流效应增加所致。这似乎可能是由于大直径孔群体数量的相对减少。
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