放射性铯在体内与两种形式的普鲁士蓝以及亚铁氰化铵铁（II）的结合。

In vivo binding of radiocesium by two forms of Prussian blue and by ammonium iron hexacyanoferrate (II).

作者信息

Dresow B, Nielsen P, Fischer R, Pfau A A, Heinrich H H

机构信息

Abteilung Medizinische Biochemic, Universitätskrankenhaus Eppendorf, Hamburg, Germany.

出版信息

J Toxicol Clin Toxicol. 1993;31(4):563-9. doi: 10.3109/15563659309025761.

DOI:10.3109/15563659309025761

PMID:8254698

Abstract

The effect of two forms of Prussian blue, soluble K3 Fe[Fe(CN)6] and insoluble Fe4[Fe(CN)6]3, and of ammonium iron hexacyanoferrate (II) (NH4Fe[Fe(CN)6] on intestinal radiocesium absorption was investigated in rats, pigs, and humans. In rats 5 mg of antidote administered 2 min before 134Cs tracer reduced radiocesium absorption to 2.4-6.3% of the oral dose. In pigs fed with Chernobyl-contaminated whey under normal feeding conditions for a 27 day period, radiocesium activity concentration was reduced from 360 Bq/kg in control animals to 10-30 Bq/kg by 5 g antidote/d. In man 1 g of oral Prussian blue diminished the cesium absorption from a 134Cs-labelled test meal to 5.6-6.4% of the controls. The inhibitory effects of colloidally soluble K3 Fe[Fe(CN)6] and of (NH4Fe[Fe(CN)6] were similar with slightly less inhibition by the insoluble Fe4[Fe(CN)6]3.

摘要

研究了两种形式的普鲁士蓝（可溶性的K3Fe[Fe(CN)6]和不溶性的Fe4[Fe(CN)6]3）以及亚铁氰化铁铵（II）（NH4Fe[Fe(CN)6]）对大鼠、猪和人体肠道放射性铯吸收的影响。在大鼠中，在给予134Cs示踪剂前2分钟给予5毫克解毒剂，可将放射性铯的吸收降低至口服剂量的2.4% - 6.3%。在正常饲养条件下，给猪喂食受切尔诺贝利污染的乳清27天，通过每天给予5克解毒剂，放射性铯活度浓度从对照动物的360贝克勒尔/千克降至10 - 30贝克勒尔/千克。在人体中，口服1克普鲁士蓝可将134Cs标记测试餐中铯的吸收降低至对照值的5.6% - 6.4%。胶体可溶性K3Fe[Fe(CN)6]和（NH4Fe[Fe(CN)6]的抑制作用相似，不溶性Fe4[Fe(CN)6]3的抑制作用略小。