大脑中GABAA受体的激活可抑制新斯的明或组胺诱导的中枢神经系统介导的高血糖症。

Activation of GABAA receptor in the brain suppresses neostigmine or histamine-induced central nervous system-mediated hyperglycemia.

作者信息

Nonogaki K, Li X, Ozawa K, Miura H, Watanabe G, Hiyoshi Y, Tamagawa T, Sakamoto N, Iguchi A

机构信息

Third Department of Internal Medicine, Nagoya University School of Medicine, Japan.

出版信息

Life Sci. 1993;53(9):PL159-63. doi: 10.1016/0024-3205(93)90255-2.

DOI:10.1016/0024-3205(93)90255-2

PMID:8394969

Abstract

We investigated the effect of GABA receptor agonists on the central nervous system (CNS)-mediated hyperglycemia induced by neostigmine or histamine in anesthetized fed rats. The injection of muscimol, GABAA receptor agonist (1, 2.5 nmol) into the third cerebral ventricle suppressed the hyperglycemia induced by intraventricular injection of neostigmine (1 x 10(-8) mol) or histamine (5 x 10(-7) mol). Baclofen, GABAB receptor agonist (1, 2.5 nmol), however, did not suppress these hyperglycemia. Neither muscimol nor baclofen (2.5 nmol) affected plasma glucose levels. These findings suggest that activation of GABAA receptor in the CNS suppresses the hyperglycemia induced by the stimulation of cholinoceptive neuron or histaminergic neuron, but activation of GABAB receptor does not affect them.

摘要

我们研究了γ-氨基丁酸（GABA）受体激动剂对麻醉的饱腹大鼠中由新斯的明或组胺诱导的中枢神经系统（CNS）介导的高血糖的影响。向第三脑室注射GABAA受体激动剂蝇蕈醇（1、2.5纳摩尔）可抑制由脑室内注射新斯的明（1×10⁻⁸摩尔）或组胺（5×10⁻⁷摩尔）诱导的高血糖。然而，GABAB受体激动剂巴氯芬（1、2.5纳摩尔）并未抑制这些高血糖。蝇蕈醇和巴氯芬（2.5纳摩尔）均未影响血浆葡萄糖水平。这些发现表明，中枢神经系统中GABAA受体的激活可抑制由胆碱能感受神经元或组胺能神经元刺激诱导的高血糖，但GABAB受体的激活对其无影响。