Miragliotta G, Mosca A, Minoia G M, Del Prete R
Istituto di Microbiologia Medica, University of Bari Medical School, Italy.
Microbios. 1993;75(305):233-40.
The effect of selected short-chain fatty acids (SCFA) produced by anaerobic bacteria on the production in vitro of procoagulant activity (PCA) by human mononuclear cells stimulated by either Escherichia coli or Bacteroides fragilis which are common pathogens in intra-abdominal infections was investigated. In particular, acetic, propionic, succinic, butyric, and isobutyric acids were evaluated. Acetic, butyric, and isobutyric acids were able to inhibit significantly the production of PCA by bacteria-stimulated mononuclear cells. Since the production of PCA leads to the deposition of fibrin which is considered critical to the establishment of intra-abdominal abscesses, the inhibitory effect exerted by SCFA present in the inflammatory environment might play an important modulating role in the development of abscesses complicating intra-abdominal infections.
研究了由厌氧细菌产生的特定短链脂肪酸（SCFA）对人单核细胞体外产生促凝血活性（PCA）的影响，这些单核细胞由大肠杆菌或脆弱拟杆菌刺激，而这两种细菌是腹腔内感染的常见病原体。特别评估了乙酸、丙酸、琥珀酸、丁酸和异丁酸。乙酸、丁酸和异丁酸能够显著抑制细菌刺激的单核细胞产生PCA。由于PCA的产生会导致纤维蛋白沉积，而纤维蛋白沉积被认为对腹腔内脓肿的形成至关重要，因此炎症环境中存在的SCFA所发挥的抑制作用可能在并发腹腔内感染的脓肿形成过程中起到重要的调节作用。
