Suzuki T, Tokuno H, Hayashi H, Egashira M, Kiyama M, Kubota K, Hirayama A, Hakuba A
Department of Neurosurgery, Tane General Hospital.
No Shinkei Geka. 1993 Nov;21(11):1049-53.
A case of metastatic spinal tumor from renal cancer reduced by interferon-alpha is reported. A 54-year-old man was admitted to Tane General Hospital on April 12, 1990, with the complaint of difficulty in walking. Abdominal CT scan revealed right renal carcinoma, and MRI demonstrated metastatic spinal tumor at Th6, which was mainly occupying the entire lamina, spinous process and right pedicle of Th6. Nephrectomy was performed and, instead of operating on the spinal lesion, the patient was given follow-up treatment with administration of interferon-alpha (5 million units twice a week) and steroid. 1 year and 6 months later the patient's walking ability began to deteriorate and paraparesis progressed, although the size of the metastatic spinal tumor had gradually reduced. This was thought to be because of atrophy of the legs due to prolonged bed rest and steroid administration. Laminectomy with total removal of the tumor was performed on January 16, 1992. In the 12 months postoperatively, there has been neither recurrence nor remote metastasis seemingly due to the administration of interferon-alpha. This appears to be the first report of metastatic spinal tumor from renal cancer reduced by interferon-alpha.
报告了一例经α-干扰素治疗后缩小的肾癌转移性脊柱肿瘤病例。一名54岁男性于1990年4月12日因行走困难入住田根综合医院。腹部CT扫描显示右肾癌，MRI显示胸6椎体有转移性脊柱肿瘤，主要占据胸6的整个椎板、棘突和右侧椎弓根。患者接受了肾切除术，未对脊柱病变进行手术，而是给予α-干扰素（每周两次，每次500万单位）和类固醇进行后续治疗。1年零6个月后，尽管转移性脊柱肿瘤的大小逐渐缩小，但患者的行走能力开始恶化，双下肢轻瘫进展。这被认为是由于长期卧床休息和使用类固醇导致腿部萎缩。1992年1月16日进行了椎板切除术并完全切除肿瘤。术后12个月，由于使用α-干扰素，似乎既没有复发也没有远处转移。这似乎是首例关于经α-干扰素治疗后缩小的肾癌转移性脊柱肿瘤的报告。
