Rammsayer T, Hennig J, Bahner E, von Georgi R, Opper C, Fett C, Wesemann W, Netter P
Department of Psychology, University of Giessen, FRG.
Neuropsychobiology. 1993;28(1-2):37-42. doi: 10.1159/000118997.
The present study was designed to compare the effects of a pharmacologically induced decrease in body core temperature to the effects observed with lowering of body temperature by exposure to a cold environment. Our special interest was the involvement of 5-HT in thermoregulatory responses. Sixty healthy male volunteers were randomly assigned to one of the following conditions: exposure to normal ambient temperature (28 degrees C) and placebo, exposure to cold ambient temperature (5 degrees C) and placebo, or normal ambient temperature and 10 mg of the partial 5-HT1A agonist ipsapirone. As indicators of physiological responses to lowering of body temperature, tympanic temperature, skin temperature, EMA, metabolic rate, and heart rate were monitored and saliva cortisol levels and peripheral 5-HT concentrations were determined. In addition, ratings on ambient temperature, thermal discomfort, and feelings of irritability were obtained. While lowering of body core temperature was associated with marked counterregulations (decrease of skin temperature, increase in EMA and metabolic rate) and feelings of discomfort, this was not observed with ipsapirone. An increase in cortisol levels was primarily observed in the ipsapirone group and was not reflected by respective changes in whole blood or platelet 5-HT indicating that brain and platelet 5-HT are not related.
本研究旨在比较药物诱导的体核温度降低与暴露于寒冷环境导致体温降低所产生的效果。我们特别关注5-羟色胺（5-HT）在体温调节反应中的作用。60名健康男性志愿者被随机分配到以下条件之一：暴露于正常环境温度（28摄氏度）并服用安慰剂、暴露于寒冷环境温度（5摄氏度）并服用安慰剂、或处于正常环境温度并服用10毫克5-HT1A部分激动剂伊沙匹隆。作为体温降低的生理反应指标，监测鼓膜温度、皮肤温度、能量代谢率（EMA）、代谢率和心率，并测定唾液皮质醇水平和外周5-HT浓度。此外，还获取了关于环境温度、热不适和易怒情绪的评分。虽然体核温度降低与明显的体温调节反应（皮肤温度降低、EMA和代谢率增加）以及不适感有关，但伊沙匹隆组未观察到这种情况。皮质醇水平升高主要在伊沙匹隆组中观察到，且全血或血小板5-HT的相应变化未反映这一点，表明脑5-HT和血小板5-HT无关。
