Opper C, Hennig J, Clement C, Laschefski U, Dey D, Dieckwisch J, Netter P, Wesemann W
Institute of Physiological Chemistry, University of Marburg, Germany.
Pharmacol Biochem Behav. 1995 Jun-Jul;51(2-3):217-21. doi: 10.1016/0091-3057(94)00432-i.
The effect of lowering body temperature on plasma epinephrine, norepinephrine, and platelet density distribution and volume was studied in a placebo-controlled double-blind study. Lowering of body core temperature was induced by either exposure to a cold environment at a temperature of 5 degrees C (CT) or by a single dose of the 5-HT1A agonist ipsapirone (IPS). A third group exposed to an ambient temperature of 28 degrees C was given placebo (PLAC). All of the three groups were investigated in a climate chamber. In the CT group the density distribution of blood platelet subpopulations was shifted to an increase in less dense platelets that were more sensitive towards aggregation-inducing agents. The mean platelet volume in this subpopulation was decreased. Epinephrine was not affected, whereas the increase of norepinephrine was correlated with an increase of platelets that were more sensitive to aggregation-inducing agents in the CT group but not in the PLAC and IPS groups.
在一项安慰剂对照双盲研究中，研究了降低体温对血浆肾上腺素、去甲肾上腺素以及血小板密度分布和体积的影响。通过暴露于5摄氏度的寒冷环境（CT组）或单次给予5-HT1A激动剂伊沙匹隆（IPS）来诱导体核温度降低。第三组暴露于28摄氏度的环境温度下，给予安慰剂（PLAC组）。所有三组均在气候舱中进行研究。在CT组中，血小板亚群的密度分布向密度较低的血小板增加方向转变，这些血小板对聚集诱导剂更敏感。该亚群中的平均血小板体积减小。肾上腺素未受影响，而去甲肾上腺素的增加与CT组中对聚集诱导剂更敏感的血小板增加相关，但在PLAC组和IPS组中并非如此。
