Marks D A, Ehrenberg B L
Department of Neurosciences, UMDNJ-New Jersey Medical School, Newark.
Neurology. 1993 Dec;43(12):2476-83. doi: 10.1212/wnl.43.12.2476.
We studied the relationship between migraine and epilepsy in 395 adult seizure patients. Seventy-nine patients (20%) also had migraine syndrome, and 13 of these patients (3%) experienced seizures during or immediately following a migraine aura. Patients with catamenial epilepsy and patients with migraine with aura were at an increased risk for an association between these two disorders. In two patients, we recorded the entire sequence from migraine aura to partial seizure, and in both there were distinctive changes on the EEG during the migraine aura that preceded the onset of an electrographic complex partial seizure. Periodic lateralized epileptiform discharges were recorded in five other patients in close temporal relation to their migraine attacks. There was improved seizure control with combination antimigraine and antiepileptic drugs (AEDs) in six patients who failed to respond to AEDs alone.
我们在395例成年癫痫患者中研究了偏头痛与癫痫之间的关系。79例患者（20%）同时患有偏头痛综合征，其中13例患者（3%）在偏头痛先兆期间或之后立即出现癫痫发作。经期癫痫患者和伴先兆偏头痛患者这两种疾病相关的风险增加。在2例患者中，我们记录了从偏头痛先兆到部分性癫痫发作的整个过程，在这两例患者中，脑电图在偏头痛先兆期间均有明显变化，随后出现脑电图复合性部分性癫痫发作。另外5例患者在与偏头痛发作密切的时间关系中记录到周期性一侧性癫痫样放电。6例单独使用抗癫痫药物（AEDs）无效的患者联合使用抗偏头痛药物和抗癫痫药物后癫痫得到更好控制。
