Simonian N A, Gilliam F G, Chiappa K H
Department of Neurology, Massachusetts General Hospital, Boston 02114.
Neurology. 1993 Dec;43(12):2700-2. doi: 10.1212/wnl.43.12.2700.
An encephalopathy characterized by confusion, stupor, and mutism frequently occurs during administration of the chemotherapeutic drug ifosfamide (IFX). We investigated two patients who developed encephalopathy during IFX infusion. Both exhibited a rapid and near-complete restoration of baseline mental status functioning concurrent with EEG improvement after administration of intravenous diazepam. We recommend an EEG and trial of benzodiazepines in patients with IFX encephalopathy.
一种以意识模糊、昏迷和缄默为特征的脑病在化疗药物异环磷酰胺（IFX）给药期间经常发生。我们调查了两名在IFX输注过程中发生脑病的患者。在静脉注射地西泮后，两人均表现出基线精神状态功能迅速且近乎完全恢复，同时脑电图有所改善。我们建议对患有IFX脑病的患者进行脑电图检查并试用苯二氮䓬类药物。
