Illyés G, Bucsek M J, Kádár A, Horányi J, Flautner L
2nd Department of Pathology, Semmelweis University of Medicine, Budapest, Hungary.
Ultrastruct Pathol. 1993 Sep-Oct;17(5):495-501. doi: 10.3109/01913129309041301.
A case of black insulinoma is reported. The color was due to a cytoplasmic pigment. Immunostaining for neuron-specific enolase and chromogranin was positive in the tumor cells, and the pigment granules themselves reacted with the chromogranin antibody. Numerous beta cell type dense core granules as well as atypical granules were found by electron microscopy. An important finding was that the dense core granules contribute to the lipofuscin pigment formation.
报告了一例黑色胰岛素瘤病例。其颜色归因于一种细胞质色素。肿瘤细胞中神经元特异性烯醇化酶和嗜铬粒蛋白免疫染色呈阳性，色素颗粒本身与嗜铬粒蛋白抗体发生反应。通过电子显微镜发现了大量β细胞型致密核心颗粒以及非典型颗粒。一个重要发现是致密核心颗粒促成了脂褐素色素的形成。
