Capella C, Usellini L, Papotti M, Macrì L, Finzi G, Eusebi V, Bussolati G
Department of Human Pathology, University of Pavia, Varese, Italy.
Ultrastruct Pathol. 1990 Jul-Aug;14(4):321-34. doi: 10.3109/01913129009032247.
The ultrastructural patterns of neuroendocrine (NE) differentiated breast carcinomas are analyzed and discussed. Reports in the literature describe wide variations in the size of observed dense-core membrane-bound granules and discrepancies in their interpretation. In the present study 24 cases of breast carcinoma with recognized morphologic, histochemical, and immunocytochemical features of NE tumors were investigated. Five different types of dense-core granules of neurosecretory (NS) type (confirmed by the ultrastructural localization of chromogranin A) and five different cell types were recognized. Some amphicrine cells were found to contain both mucin and NS granules. Another notable ultrastructural feature of breast NE carcinomas was the presence of clear vesicles of presynaptic type, which correlated with expression of synaptophysin.
对神经内分泌（NE）分化型乳腺癌的超微结构模式进行了分析和讨论。文献报道显示，观察到的致密核心膜结合颗粒大小存在广泛差异，且对其解释也存在分歧。在本研究中，对24例具有公认的NE肿瘤形态学、组织化学和免疫细胞化学特征的乳腺癌病例进行了调查。识别出了五种不同类型的神经分泌（NS）型致密核心颗粒（通过嗜铬粒蛋白A的超微结构定位证实）和五种不同的细胞类型。发现一些双分泌细胞同时含有粘蛋白和NS颗粒。乳腺NE癌的另一个显著超微结构特征是存在突触前型清亮小泡，这与突触素的表达相关。
