Shapiro S H, Klavins J V
Queens Hospital Center, Department of Laboratories, Jamaica, New York 11432.
Ultrastruct Pathol. 1993 Sep-Oct;17(5):557-63. doi: 10.3109/01913129309041307.
The cytoplasm of hepatocytes in a liver biopsy from a patient with acquired immunodeficiency syndrome (AIDS) treated with sulfamethazole-trimethoprim contained concentric membranous bodies (CMB) and giant mitochondria. By light microscopy the general architecture of the liver was unaltered. By electron microscopy one to three CMB were present in random distribution within several cells in equal periportal and centrilobular localization. CMB were irregularly rounded or ovoid, loosely ribosome-studded lamellar whorls. Some were agranular or in parallel arrangement. Giant mitochondria often with paracrystalline inclusions were frequently in close association with CMB. Tubuloreticular inclusions were noted in Kupffer cell cytoplasm. Since CMB have been infrequently observed in human hepatocytes, are rare in nonneoplastic human liver, and have not been previously reported in association with AIDS, their appearance may relate to regenerative changes and/or sulfamethazole-trimethoprim therapy.
在接受磺胺甲恶唑 - 甲氧苄啶治疗的获得性免疫缺陷综合征（AIDS）患者的肝脏活检中，肝细胞的细胞质含有同心膜性小体（CMB）和巨大线粒体。光学显微镜下，肝脏的总体结构未改变。电子显微镜下，在门周和小叶中心区域的几个细胞内随机分布着一到三个CMB。CMB呈不规则圆形或椭圆形，为核糖体稀疏的松散层状涡旋结构。有些无颗粒或呈平行排列。常伴有类晶体包涵体的巨大线粒体常与CMB紧密相连。在库普弗细胞的细胞质中发现了管状网状包涵体。由于CMB在人类肝细胞中很少被观察到，在非肿瘤性人类肝脏中罕见，且此前未报道与AIDS相关，其出现可能与再生变化和/或磺胺甲恶唑 - 甲氧苄啶治疗有关。
