Pilewski J M, Albelda S M
Department of Medicine, University of Pennsylvania, Philadelphia.
Am Rev Respir Dis. 1993 Dec;148(6 Pt 2):S31-7. doi: 10.1164/ajrccm/148.6_Pt_2.S31.
Several distinct cell adhesion molecule families have recently been identified and found to be important in the inflammatory response and for epithelial and endothelial homeostasis. The integrin family of adhesion molecules functions in both cell-matrix and cell-cell interactions, whereas the cadherins serve as important cell-cell receptors for maintenance of epithelial integrity. The leukocyte integrins, selectins, members of the immunoglobulin supergene family, and specific carbohydrates mediate adhesive interactions between leukocytes and endothelial cells. The mechanisms of leukocyte-epithelial adhesion are less well understood, but integrins and members of the immunoglobulin supergene family are also involved. The role of these molecules in pulmonary structure and inflammation is currently being actively explored. Further knowledge of these interactions, and the interplay of adhesion molecules, cytokines, and chemoattractants is likely to lead to novel therapeutic modalities in inflammatory diseases of the airway and lung parenchyma. In this overview, the families of adhesion molecules will be summarized, and their relevance for pulmonary structure and inflammation will be discussed.
最近已经鉴定出几个不同的细胞粘附分子家族，发现它们在炎症反应以及上皮和内皮稳态中起重要作用。粘附分子的整合素家族在细胞 - 基质和细胞 - 细胞相互作用中均发挥作用，而钙粘蛋白作为维持上皮完整性的重要细胞 - 细胞受体。白细胞整合素、选择素、免疫球蛋白超基因家族成员和特定碳水化合物介导白细胞与内皮细胞之间的粘附相互作用。白细胞与上皮细胞粘附的机制了解较少，但整合素和免疫球蛋白超基因家族成员也参与其中。目前正在积极探索这些分子在肺结构和炎症中的作用。对这些相互作用以及粘附分子、细胞因子和趋化因子之间相互作用的进一步了解可能会带来气道和肺实质炎症性疾病的新型治疗方法。在本综述中，将总结粘附分子家族，并讨论它们与肺结构和炎症的相关性。
