Schüssler P, Kruis W, Marget W
Med Klin. 1976 Oct 29;71(44):1898-902.
In 18 patients with Crohn's disease, 28 patients with ulcerative colitis, 24 patients with acute enteritis and in 68 healthy adults lipid A antibody titers were determined by the passive hemolysis test. In addition O antibody titers to polyvalent Escherichia coli, Klebsiella, Proteus and Pseudomonas aeruginosa antigens were measured by indirect hemagglutination. The patients with Crohn's disease showed a statistically significant elevation of the lipid A antibody titers compared with each of the three other groups investigated. The O antibody titers for the four polyvalent antigens were higher in the patients with Crohn's disease than in the other groups. The results indicate that Enterobacteriaceae are involved in the pathogenesis of Crohn's disease. Thus, long-term treatment with wide spectrum antibiotics seems to be justified. The determination of lipid A antibody titers may be useful in differentiating between Crohn's disease and ulcerative colitis on diagnosis.
对18例克罗恩病患者、28例溃疡性结肠炎患者、24例急性肠炎患者以及68名健康成年人，采用被动溶血试验测定脂多糖A抗体滴度。此外，通过间接血凝法检测针对多价大肠杆菌、克雷伯菌、变形杆菌和铜绿假单胞菌抗原的O抗体滴度。与其他三组被调查对象相比，克罗恩病患者的脂多糖A抗体滴度有统计学意义的升高。克罗恩病患者针对四种多价抗原的O抗体滴度高于其他组。结果表明肠杆菌科细菌参与了克罗恩病的发病机制。因此，长期使用广谱抗生素治疗似乎是合理的。测定脂多糖A抗体滴度可能有助于在诊断时区分克罗恩病和溃疡性结肠炎。
