Kruis W, Paulus W, Fateh-Moghadam A, Schüssler P, Eisenburg J
Z Gastroenterol. 1981 Jun;19(6):276-83.
The results of previously published studies on serum immunoglobulin concentrations in patients with Crohn's disease are controversial. Therefore a long term study of serum immunoglobulin concentrations comparing 31 patients with Crohn's disease was carried out. The serum IgM concentrations of patients with active disease was significantly lower than the serum IgM concentration in patients with inactive disease. 7/25 patients who were all treated with steroids had an elevated serum IgE concentrations. It could not be demonstrated that serum immunoglobulin concentrations are influenced by steroids, by bowel resection or by the activity of the disease. As no characteristic change of serum immunoglobulin concentration in patients with Crohn's disease could be found the determination of serum immunoglobulins seems to be of no clinical value. Furthermore a possible connection between serum immunoglobulin concentrations and antibody titers against the lipid A component of endotoxins was investigated: Serum IgM concentrations were significantly higher in patients with elevated lipid-A-antibody titers than in patients with normal lipid-A-antibody titers. Thus indicates a specific antibody formation to endotoxins and lipid A, respectively.
先前发表的关于克罗恩病患者血清免疫球蛋白浓度的研究结果存在争议。因此，开展了一项长期研究，比较31例克罗恩病患者的血清免疫球蛋白浓度。活动期疾病患者的血清IgM浓度显著低于非活动期疾病患者的血清IgM浓度。25例均接受类固醇治疗的患者中有7例血清IgE浓度升高。无法证明血清免疫球蛋白浓度受类固醇、肠道切除术或疾病活动度的影响。由于未发现克罗恩病患者血清免疫球蛋白浓度有特征性变化，血清免疫球蛋白的测定似乎没有临床价值。此外，还研究了血清免疫球蛋白浓度与抗内毒素脂质A成分抗体滴度之间可能存在的联系：脂质A抗体滴度升高的患者血清IgM浓度显著高于脂质A抗体滴度正常的患者。这分别表明针对内毒素和脂质A形成了特异性抗体。
