Freese J A, Rossouw E J, Gouws E, Sharp B L, Markus M B
Medical Research Council, Congella, South Africa.
Ann Trop Med Parasitol. 1993 Jun;87(3):235-9. doi: 10.1080/00034983.1993.11812761.
Twenty southern African isolates of Plasmodium falciparum and a 'control' Gambian strain were tested in vitro for their sensitivity to halofantrine. The concentration required to inhibit 50% of parasite growth, the IC50, ranged from 0.039 to 15.000 nmol/litre, with a mean of 4.619 nmol/litre. These IC50 values were comparable with those obtained in studies carried out in West Africa but were higher than the IC50 of South-East Asian isolates. All 21 isolates examined in the present study had minimum inhibitory concentrations (MIC) of 32 nmol/litre or less, with a median MIC value of 8 nmol/litre. Halofantrine was equally active against chloroquine-sensitive and chloroquine-resistant isolates and was also active against pyrimethamine-resistant strains. Indications are that this drug would be suitable for the treatment of P. falciparum malaria in the southern African region.
对20株来自非洲南部的恶性疟原虫分离株和1株“对照”冈比亚菌株进行了体外氯氟菲醇敏感性测试。抑制50%寄生虫生长所需的浓度，即半数抑制浓度（IC50），范围为0.039至15.000纳摩尔/升，平均为4.619纳摩尔/升。这些IC50值与在西非进行的研究中获得的值相当，但高于东南亚分离株的IC50。本研究中检测的所有21株分离株的最低抑菌浓度（MIC）均为32纳摩尔/升或更低，MIC中值为8纳摩尔/升。氯氟菲醇对氯喹敏感和氯喹耐药的分离株同样有效，对乙胺嘧啶耐药菌株也有效。有迹象表明，这种药物适用于非洲南部地区恶性疟原虫疟疾的治疗。
