Vorberg G
MMW Munch Med Wochenschr. 1976 Oct 29;118(44):1429-32.
Over a period of 6 weeks, 90 patients of both sexes (principally male) aged from 38 to 81 years were treated with Nico-Padutin forte (BAY b 7979; 40 units kallikrein + 300 mg inositol nicotinate) for chronic arterial disorders of the lower extremities. Positive therapeutic results were obtained in 82 cases (91.2%) with a dosage of 1 tablet 3 times daily. The effect of the treatment was assessed by the cardinal symptom of intermittent claudication. The walking test was used as the clinical parameter. The significant lowering of the raised blood lipid levels (both in the cholesterol and triglyceride ranges) by treatment with BAY b 7979 is to be considered relevant in the importance of hyperlipidemia as a risk factor in arterial vascular diseases. As long as the controindications (acute myocardial infarction, acute hemorrhages) were given attention, tolerance was outstanding.
在为期6周的时间里，对90名年龄在38岁至81岁之间的男女患者（主要为男性）使用尼可保妥因强力片（BAY b 7979；40单位激肽释放酶 + 300毫克烟酸肌醇酯）治疗下肢慢性动脉疾病。每日3次，每次1片的剂量使82例（91.2%）患者获得了积极的治疗效果。通过间歇性跛行的主要症状评估治疗效果。步行试验用作临床参数。考虑到高脂血症作为动脉血管疾病风险因素的重要性，用BAY b 7979治疗后血脂水平（胆固醇和甘油三酯范围）显著降低具有重要意义。只要注意禁忌证（急性心肌梗死、急性出血），耐受性就非常好。
