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One year treatment with low dose methotrexate in rheumatoid arthritis: effect on class specific rheumatoid factors.

作者信息

Spadaro A, Riccieri V, Sili Scavalli A, Taccari E, Zoppini A

机构信息

Institute of Rheumatology, University of Rome La Sapienza, Policlinico Umberto I, Italy.

出版信息

Clin Rheumatol. 1993 Sep;12(3):357-60. doi: 10.1007/BF02231579.

DOI:10.1007/BF02231579
PMID:8258236
Abstract

We evaluated the effect of a one-year treatment of low dose methotrexate (MTX) on class specific rheumatoid factors in 27 patients with rheumatoid arthritis (RA). Enzyme-linked immunosorbent assay (ELISA) showed after 6 and 12 months a significant reduction of IgM-RF, IgA-RF and IgG-RF levels from the baseline values. During MTX treatment, changes of each RF isotype were not correlated with any other isotype and its corresponding immunoglobulin changes. Moreover, immunological changes were not related to the improvement of clinical parameters. Our results showed that low dose MTX can specifically affect levels of RF isotypes, which are involved in the immune pathogenesis of RA.

摘要

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本文引用的文献

1
IgG and IgM rheumatoid factors in rheumatoid arthritis. Quantitative response to penicillamine therapy and relationship to disease activity.类风湿关节炎中的IgG和IgM类风湿因子。对青霉胺治疗的定量反应及其与疾病活动的关系。
Arthritis Rheum. 1983 May;26(5):593-8. doi: 10.1002/art.1780260503.
2
Serum IgG and IgM rheumatoid factors by solid phase radioimmunoassay. A comparison between adult and juvenile rheumatoid arthritis.通过固相放射免疫测定法检测血清IgG和IgM类风湿因子。成人与青少年类风湿性关节炎的比较。
Arthritis Rheum. 1981 Dec;24(12):1501-11. doi: 10.1002/art.1780241208.
3
Use of monoclonal antibodies and F(ab')2 enzyme conjugates in ELISA for IgM, IgA and IgG rheumatoid factors.
类风湿关节炎患者在小剂量甲氨蝶呤治疗期间可溶性白细胞介素-2受体和白细胞介素-6的变化
Clin Rheumatol. 1996 Mar;15(2):218-9. doi: 10.1007/BF02230349.
单克隆抗体和F(ab')2酶结合物在用于检测IgM、IgA和IgG类风湿因子的酶联免疫吸附测定（ELISA）中的应用。
J Immunol Methods. 1984 Jul 6;71(2):149-61. doi: 10.1016/0022-1759(84)90061-9.
4
Effect of D-penicillamine on serum immunoglobulins and rheumatoid factor.青霉胺对血清免疫球蛋白及类风湿因子的影响。
Ann Rheum Dis. 1973 Jan;32(1):50-2. doi: 10.1136/ard.32.1.50.
5
Gamma globulin complexes in synovial fluids of patients with rheumatoid arthritis. Partial characterization and relationship to lowered complement levels.类风湿性关节炎患者滑液中的γ球蛋白复合物。部分特性及与补体水平降低的关系。
Clin Exp Immunol. 1970 May;6(5):689-706.
6
Weekly pulse methotrexate in rheumatoid arthritis. Clinical and immunologic effects in a randomized, double-blind study.类风湿关节炎的每周一次脉冲式甲氨蝶呤治疗。一项随机双盲研究中的临床和免疫学效应
Ann Intern Med. 1985 Oct;103(4):489-96. doi: 10.7326/0003-4819-103-4-489.
7
Measurement of rheumatoid factors by an enzyme-linked immunosorbent assay (ELISA) and comparison with other methods.通过酶联免疫吸附测定法（ELISA）检测类风湿因子并与其他方法进行比较。
Ann Rheum Dis. 1985 Jan;44(1):13-9. doi: 10.1136/ard.44.1.13.
8
Comparison of low-dose oral pulse methotrexate and placebo in the treatment of rheumatoid arthritis. A controlled clinical trial.低剂量口服脉冲甲氨蝶呤与安慰剂治疗类风湿关节炎的比较：一项对照临床试验
Arthritis Rheum. 1985 Jul;28(7):721-30. doi: 10.1002/art.1780280702.
9
The safety and efficacy of the use of methotrexate in long-term therapy for rheumatoid arthritis.甲氨蝶呤用于类风湿关节炎长期治疗的安全性和有效性。
Arthritis Rheum. 1986 Jul;29(7):822-31. doi: 10.1002/art.1780290702.
10
Immunologic studies of rheumatoid arthritis patients treated with methotrexate.
Arthritis Rheum. 1987 May;30(5):481-8. doi: 10.1002/art.1780300501.