Kilshaw P J
Department of Immunology, AFRC Babraham Institute, Cambridge GB.
Eur J Immunol. 1993 Dec;23(12):3365-8. doi: 10.1002/eji.1830231246.
Dendritic interdigitating cells isolated from lymph nodes, Langerhans' cells from skin and dendritic cells from the spleen have been tested for expression of the mucosal T cell integrin alpha M290 beta 7. Almost all interdigitating cells isolated from mesenteric lymph nodes expressed the integrin at high levels; 50-60% of those from lymph nodes draining non-mucosal sites also expressed this adhesion molecule. In contrast, alpha M290 beta 7 was not detected on either Langerhans' cells or splenic dendritic cells. Because this integrin has recently been shown to recognize a ligand that seems to be expressed mainly or exclusively by epithelial cells; it is proposed that this adhesion pathway may be important for antigen sampling by dendritic cells in mucosal tissues.
从淋巴结分离出的树突状交错突细胞、从皮肤分离出的朗格汉斯细胞以及从脾脏分离出的树突状细胞，已被检测是否表达黏膜T细胞整合素αM290β7。几乎所有从肠系膜淋巴结分离出的交错突细胞都高水平表达该整合素；来自非黏膜部位引流淋巴结的细胞中，50%-60%也表达这种黏附分子。相比之下，在朗格汉斯细胞或脾树突状细胞上均未检测到αM290β7。由于最近已表明这种整合素能识别一种似乎主要或仅由上皮细胞表达的配体；因此有人提出，这种黏附途径可能对黏膜组织中树突状细胞的抗原采样很重要。
