Matioli G T
USC School of Medicine, Los Angeles 90033.
Med Hypotheses. 1993 Sep;41(3):251-5. doi: 10.1016/0306-9877(93)90242-i.
The paper discusses a mechanism for the coordination of a differentiation path through activation of slave genes by transcriptional complexes (excitons) organised by master genes. Entrainment occurs when master-slave genes form partnerships of closely apposed entities. Sister chromatid exchanges provide the action necessary for successful entrainment. Although concerned mainly with normal hematopoietic (stem) cells, the model applies also to certain leukemic cells, regarding in particular retrodifferentiation back to the stem state followed by attenuation of malignancy.
本文讨论了一种通过主基因组织的转录复合物（激子）激活从基因来协调分化途径的机制。当主从基因形成紧密相邻实体的伙伴关系时，就会发生同步。姐妹染色单体交换为成功同步提供了必要的作用。虽然该模型主要涉及正常造血（干）细胞，但也适用于某些白血病细胞，特别是关于向干细胞状态的逆向分化，随后恶性程度减弱。
