Jouanny P, Schmidt C, Feldmann L, Schmitt J
Secteur d'Angiologie, Hôpital central, CHU de Nancy.
Presse Med. 1993 Sep 18;22(27):1256-60.
The diagnostic value of nailfold capillaroscopy was assessed through blind analysis of a continuous series of 354 examinations. Major and minor dystrophies and capillary bed abnormalities are the best criteria, especially in patients presenting with vascular disorders of the upper extremities. A systemic disease (specificity: 82.7 percent; negative predictive value (NPV): 90.2 percent) and specifically a systemic scleroderma (sensitivity: 97.1 percent and NPV: 99.4 percent) is improbable in case of normal capillaroscopy. First component analysis distinguished patients with definite systemic disease from normal subjects. Its value is dubious in other connective tissue diseases systemic lupus erythematosus, rheumatoid arthritis, Sjögren's disease, etc.).
通过对连续354例检查进行盲法分析，评估了甲襞毛细血管镜检查的诊断价值。主要和次要营养不良以及毛细血管床异常是最佳标准，尤其是在上肢血管疾病患者中。毛细血管镜检查正常时，全身性疾病（特异性：82.7%；阴性预测值（NPV）：90.2%），特别是系统性硬化症（敏感性：97.1%，NPV：99.4%）不太可能存在。主成分分析将确诊全身性疾病的患者与正常受试者区分开来。其在其他结缔组织疾病（系统性红斑狼疮、类风湿性关节炎、干燥综合征等）中的价值存疑。
