Giercksky K E, Bjorklid E
Scand J Haematol. 1976 Oct;17(4):305-11. doi: 10.1111/j.1600-0609.1976.tb01189.x.
Infusions of purified tissue thromboplastin in rats cause the accumulation of fibrin and platelets in the lungs and produce marked changes in the platelet count and in the coagulation factors V, VII and VIII. Tissue thromboplastin in a dose corresponding to less than 2 mug of protein per rat is lethal when given as a bolus injection. Simultaneous i.v. administration purified phospholipase C effectively prevents all these changes and protects rats from otherwise lethal doses of tissue thromboplastin. The necessary doses of phospholipase C are well below the toxic level for phospholipase C alone.
给大鼠输注纯化的组织凝血活酶会导致肺中纤维蛋白和血小板的积聚，并使血小板计数以及凝血因子V、VII和VIII发生显著变化。以每只大鼠低于2微克蛋白质的剂量给予组织凝血活酶进行推注注射时是致命的。同时静脉内给予纯化的磷脂酶C可有效防止所有这些变化，并保护大鼠免受原本致命剂量的组织凝血活酶的影响。所需的磷脂酶C剂量远低于单独使用磷脂酶C的毒性水平。
