Vítovec J, Vladík P, Záhor Z, Slabý V
Vet Med (Praha). 1976;21(6):359-68.
Seventy cases of morphologically developed cases or brucellosis in hares are described. Twenty-five of the cases were tested by the cultivation methods and the causative agent was identified as Brucella suis. In females the authors found 57 cases, in males 13 cases. Brucellosis of hares was characterized by a chronical course, by a conspicuous local progression, and by a predominance of pathological changes in the reproductive organs of both sexes. Males showed changes mainly on testes. Nodal, solitary as well as multiple lesions in the parametrium near the uterine wall were particularly typical of females. The hematogenous propagation of brucellosis affected mostly liver and spleen, frequently showing conspicuously large nodes with irregular sides resulting from the growh of the deposits through apposition. The microscopic basis of the changes due to brucellosis was represented by granulomas of histiocytic character with a conspicuously small pyogenic component penetrated by necrosis of a caseous character, rich in lipoids. In comparison with tuberculosis, the brucellosis inflammation in hares shows a conspicuous cellular and nuclear variability in the histiocytic layer of granulomas, prevalent caryloytic disintegration of cellular elements, frequent finding of eosinophiles, and non-constant occurrence of giant multinuclear elements of Langhans cell type.
描述了70例野兔形态学上已发展的病例或布鲁氏菌病病例。其中25例通过培养方法进行了检测，病原体被鉴定为猪布鲁氏菌。作者发现雌性有57例，雄性有13例。野兔布鲁氏菌病的特点是病程呈慢性，局部进展明显，且两性生殖器官的病理变化占优势。雄性主要表现为睾丸病变。子宫壁附近子宫旁组织中的结节状、孤立性以及多发性病变在雌性中尤为典型。布鲁氏菌病的血行传播主要影响肝脏和脾脏，常常可见明显的大结节，其边缘不规则，这是由于沉积物通过附着生长所致。布鲁氏菌病所致变化的微观基础表现为具有组织细胞特征的肉芽肿，化脓性成分明显较少，有干酪样坏死灶，富含类脂。与结核病相比，野兔的布鲁氏菌病炎症在肉芽肿的组织细胞层中表现出明显的细胞和核的变异性，细胞成分普遍出现核溶解崩解，经常发现嗜酸性粒细胞，且朗汉斯细胞型多核巨细胞并非经常出现。
