[Glycogen and enzymes involved in its biosynthesis in rat liver during liver carcinogenesis caused by diethylnitrosamine].

An attempt was made to correlate variations in the level of glycogen during chemically induced carcinogenesis (DENA) with changes in the activity of enzymes participating in biosynthesis of this polysaccharide (UDPG-glycosensynthetase, phosphoglucomutase, UDPG-pyrophosphorylase). It is found that in DENA action in the rat liver two phases may be sharply differentiated--initial (the 1st month) with marked alterations in the content of glycogen and the activity of related enzymes, and final one (4-6th month) which is characterized by reduction of glycogen content, a new sharp rise in the activity of phosphoglucomutase and UDPG-pyrophosphorylase, and somewhat decreased activity of UDPG-glycogensynthetase, as compared with the initial values.