Wainwright R J, Foran J P, Padaria S F, Akhras F, Jackson G, Clark A R
Department of Cardiology, Brook General Hospital, London.
Br J Clin Pract. 1993 Jul-Aug;47(4):178-82.
The safety and tolerability of intermittent (16 hours on/8 hours off) nitrate patch therapy (0.2, 0.4 or 0.6 mg/hr: dose adjusted as required) was studied for a median duration of 356 days in 106 patients (mean age 60.9 +/- 8.6 years) with angina pectoris. Most patients (82%) were on existing beta-blocker and/or calcium antagonist therapy. Safety, tolerability and efficacy data were obtained by means of patient diary cards and regular clinic visits. Almost 90 treatment years revealed no significant or serious adverse events, and there were no changes in haematology or biochemistry associated with intermittent nitrate patch therapy. The most frequently reported side-effects were headache, skin reactions and dizziness (53%, 20% and 8% of patients respectively). Treatment resulted in a sustained reduction in the frequency and severity of angina attacks, reduced sublingual GTN consumption, an improvement in general wellbeing and a rise in the proportion of patients in whom angina was controlled.
对106例（平均年龄60.9±8.6岁）心绞痛患者进行了为期356天（中位数）的间歇性（16小时使用/8小时停用）硝酸酯贴片治疗（0.2、0.4或0.6毫克/小时：根据需要调整剂量）的安全性和耐受性研究。大多数患者（82%）正在接受现有的β受体阻滞剂和/或钙拮抗剂治疗。通过患者日记卡和定期门诊就诊获取安全性、耐受性和疗效数据。近90个治疗年未发现显著或严重不良事件，且间歇性硝酸酯贴片治疗未引起血液学或生物化学方面的变化。最常报告的副作用是头痛、皮肤反应和头晕（分别占患者的53%、20%和8%）。治疗使心绞痛发作的频率和严重程度持续降低，舌下含服硝酸甘油的用量减少，总体健康状况改善，心绞痛得到控制的患者比例增加。
