Kounis N G, Zavras G M, Papadaki P J, Soufras G D, Poulos E A, Goudevenos J, Alangoussis A, Antonakopoulos K, Frangides C, Peristeropoulou S A, Koutsojannis C
Department of Medicine, Agios Andreas General Hospital, Patras, Greece.
Br J Clin Pract. 1996 Dec;50(8):437-9.
To assess the exact cause and extent of transdermal glyceryl trinitrate (GTN)-induced allergic reactions, a study of continuous and intermittent use of GTN patches was conducted in 320 patients with New York Heart Association (NYHA) class II and III angina pectoris. Three commercially available GTN patch systems were used. Twenty-one patients (6.5%) developed cutaneous reactions. In 17 patients (5.3%), the reactions were confined to the area of application and were characterised as irritant reactions. Four patients (1.2%) developed both localised and remote from the area of application lesions and one patient developed a generalised anaphylactic reaction. The rate of discontinuation of therapy was 3.4%. The irritant skin reactions were mainly due to contaminants and additives. Changing to a different transdermal system reduced the incidence of local reactions--a particularly desirable effect in patients who respond well to GTN therapy.
为评估经皮硝酸甘油（GTN）引起过敏反应的确切原因及程度，对320例纽约心脏协会（NYHA）II级和III级心绞痛患者进行了一项关于连续和间歇使用GTN贴片的研究。使用了三种市售的GTN贴片系统。21例患者（6.5%）出现皮肤反应。17例患者（5.3%）的反应局限于贴片应用部位，表现为刺激性反应。4例患者（1.2%）在贴片应用部位及其他部位出现皮损，1例患者发生全身性过敏反应。治疗中断率为3.4%。刺激性皮肤反应主要归因于污染物和添加剂。更换为不同的经皮给药系统可降低局部反应的发生率——这对GTN治疗反应良好的患者来说是一个特别理想的效果。
