Whitlock J A, McCurley T L
Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232-2588.
Leuk Lymphoma. 1993 Oct;11(3-4):299-303. doi: 10.3109/10428199309087008.
A fourteen month old boy presented with hepatosplenomegaly and pancytopenia. An extensive evaluation, including bone marrow aspiration and biopsies of both liver and lymph nodes, revealed a polyclonal B cell proliferation consistent with a reactive process, with no evidence of leukemia. After receiving transfusions of red cells and platelets, his blood counts recovered. Five weeks later, he returned with an elevated white blood count and bone marrow findings diagnostic of acute lymphocytic leukemia. The leukemic blasts contained a novel chromosomal translocation, t(5;14) (q34;q12). We describe the clinical, immunophenotypic and cytogenetic features of this case, review the literature of acute lymphocytic leukemia associated with a preleukemic phase, and discuss the relationship of this clinical entity to the 5q-abnormality associated with myelodysplasia.
一名14个月大的男童出现肝脾肿大和全血细胞减少。包括骨髓穿刺以及肝脏和淋巴结活检在内的全面评估显示，存在与反应性过程一致的多克隆B细胞增殖，无白血病证据。在输注红细胞和血小板后，他的血细胞计数恢复正常。五周后，他再次就诊，白细胞计数升高，骨髓检查结果诊断为急性淋巴细胞白血病。白血病原始细胞含有一种新的染色体易位，即t(5;14)(q34;q12)。我们描述了该病例的临床、免疫表型和细胞遗传学特征，回顾了与白血病前期相关的急性淋巴细胞白血病的文献，并讨论了这一临床实体与骨髓增生异常相关的5q异常之间的关系。
