Cowan K M, Erol N, Whiteland A P
J Gen Virol. 1978 Nov;41(2):437-42. doi: 10.1099/0022-1317-41-2-437.
Antigenic differences were demonstrated between the large and small plaque variants of both types O1 and Asia-1 foot-and-mouth disease viruses. Treatment of the large and small plaque variants of the viruses with trypsin essentially abolished the observed antigenic differences. Thus, these plaque variants have antigenically different trypsin-sensitive determinants that may influence their immunogenicity and infection capabilities.
O1型和亚洲1型口蹄疫病毒的大、小蚀斑变种之间存在抗原差异。用胰蛋白酶处理病毒的大、小蚀斑变种基本上消除了所观察到的抗原差异。因此，这些蚀斑变种具有抗原性不同的对胰蛋白酶敏感的决定簇，这些决定簇可能会影响它们的免疫原性和感染能力。
