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[悬浮细胞培养中繁殖的口蹄疫病毒的若干评估标准]

[Several criteria of evaluation of foot-and-mouth disease virus reproduced in cell cultures in suspension].

作者信息

Girard H C

出版信息

Dev Biol Stand. 1976;35:91-6.

PMID:71255
Abstract

The study of the plaques produced by viruses Asia and O1 reveals different properties which may depend on the virus or on the cell or its method of culture. Antigenic differences and subsequent immunological differences correspond to differences in plaques. On the other hand, the cell line in suspension evolves both in its morphology and its receptivity during the passages. All these variations imply the observations of quantitative and qualitative criteria of evaluation in order to prepare vaccines from viruses similar to viruses specific to a given epizooty.

摘要

对亚洲病毒和O1病毒产生的噬菌斑的研究揭示了不同的特性,这些特性可能取决于病毒、细胞或其培养方法。抗原差异及随后的免疫差异与噬菌斑的差异相对应。另一方面,悬浮培养的细胞系在传代过程中其形态和接受能力都会发生变化。所有这些变化都意味着要观察评估的定量和定性标准,以便从类似于特定 epizooty 特有的病毒的病毒中制备疫苗。

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