局部应用抗胆碱酯酶药物后猴眼房水流出系统对毛果芸香碱的敏感性降低。
Subsensitivity to pilocarpine of the aqueous outflow system in monkey eyes after topical anticholinesterase treatment.
作者信息
Kaufman P L, Bárány E H
出版信息
Am J Ophthalmol. 1976 Dec;82(6):883-91. doi: 10.1016/0002-9394(76)90065-9.
PMID:826164
Abstract
Cynomolgus and vervet monkeys were treated unilaterally with topical echothiophate iodide twice daily for eight to 25 weeks. The effect of intracameral pilocarpine on outflow facility was determined in the ganglionic-blocked animal during and after echothiophate treatment. The echothiophate-treated eyes demonstrated marked subsensitivity to pilocarpine, and required several weeks to months to recover normal pilocarpine sensitivity.
摘要
食蟹猴和绿猴每天接受两次局部碘磷定治疗，持续8至25周，治疗为单侧。在碘磷定治疗期间和之后，在神经节阻断的动物中测定前房内毛果芸香碱对房水流畅系数的影响。经碘磷定治疗的眼睛对毛果芸香碱表现出明显的敏感性降低，需要数周至数月才能恢复正常的毛果芸香碱敏感性。
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