Hasegawa S, Kato K, Takashi M, Zhu Y, Obata K, Miyake K
Department of Urology, Nagoya University School of Medicine, Japan.
Eur Urol. 1993;24(3):393-6. doi: 10.1159/000474335.
We assayed serum and urine S100a0 protein levels in patients with renal stones (n = 21) or ureteral stones (n = 18), before and after extracorporeal shock wave lithotripsy (ESWL) to evaluate tissue injury. Serum S100a0 protein levels increased significantly immediately after, and at 2 and 24 h after ESWL in patients with renal stones, and at 2 and 24 h after ESWL in patients with ureteral stones. Significant increases in urine S100a0 protein levels were observed immediately and 2 h after ESWL in both groups of patients. The patients receiving a higher number of shock waves had a more pronounced increase in serum S100a0 protein especially in the case of more than 3,500 shock waves. Because S100a0 protein exists at relatively high concentrations in the proximal renal tubules and skeletal muscles, serum and urine S100a0 protein levels appear to be useful markers of tissue injury, including damage in the kidney and skeletal muscles, in the early post-ESWL phase.
我们检测了肾结石患者（n = 21）或输尿管结石患者（n = 18）在体外冲击波碎石术（ESWL）前后的血清和尿液S100a0蛋白水平，以评估组织损伤。肾结石患者在ESWL后即刻、2小时和24小时，以及输尿管结石患者在ESWL后2小时和24小时，血清S100a0蛋白水平均显著升高。两组患者在ESWL后即刻和2小时尿液S100a0蛋白水平均显著升高。接受冲击波次数较多的患者血清S100a0蛋白升高更为明显，尤其是在冲击波次数超过3500次的情况下。由于S100a0蛋白在近端肾小管和骨骼肌中浓度相对较高，血清和尿液S100a0蛋白水平似乎是ESWL后早期包括肾脏和骨骼肌损伤在内的组织损伤的有用标志物。
