Chastikova A V, Starostina Z D, Kislova T A
Antibiotiki. 1976 Oct;21(10):942-5.
The dynamics of the changes in sensitivity of gonococci to penicillin within 1958-1974 was studied. It was shown that penicillin sensitivity of gonococci decreased. The sensitivty of gonococci was transferred on passages which explains predominant isolation of the resistant strains from males with fresh gonorrhea and from females with chronic gonorrhea and girls. Gonococci with low sensitivity levels to penicillin were isolated from most of the patients with complicated and ascending forms of gonorrhea. The resistance development was often preceded by irrational and incompleted therapy.
研究了1958年至1974年间淋球菌对青霉素敏感性变化的动态。结果表明，淋球菌对青霉素的敏感性降低。淋球菌的敏感性在传代过程中发生转移，这解释了为何在新发淋病男性患者、慢性淋病女性患者及女童中耐药菌株占主导地位。大多数患有复杂性及上行性淋病的患者分离出了对青霉素敏感性较低的淋球菌。耐药性的产生往往先于不合理及不完整的治疗。
