Kiss Z, Crilly K S, Anderson W H
Hormel Institute, University of Minnesota, Austin, MN 55912.
FEBS Lett. 1993 Dec 20;336(1):115-8. doi: 10.1016/0014-5793(93)81622-7.
Many human tumors contain high concentrations of ethanolamine phosphate (EtnP). An important question is whether increased formation of EtnP is merely the consequence of cell transformation, or is it associated with the process of carcinogenesis. Here we show that in C3H/10T1/2 embryonic fibroblasts, an established cellular model for the study of carcinogenesis, the environmental carcinogens, 7,12-dimethylbenz[a]anthracene (DMBA) and benzo[a]pyrene (B[a]P) (0.1-1 microgram/ml concentration; 24 h treatment), stimulate phosphorylation of ethanolamine derived from increased hydrolysis of phosphatidylethanolamine. The results suggest that increased formation of EtnP is associated with the early stages of carcinogenesis. This observation may have prognostic value.
许多人类肿瘤中含有高浓度的磷酸乙醇胺（EtnP）。一个重要的问题是，EtnP生成增加仅仅是细胞转化的结果，还是与致癌过程相关。在这里我们表明，在C3H/10T1/2胚胎成纤维细胞（一种用于研究致癌作用的成熟细胞模型）中，环境致癌物7,12-二甲基苯并[a]蒽（DMBA）和苯并[a]芘（B[a]P）（浓度为0.1-1微克/毫升；处理24小时），刺激了由磷脂酰乙醇胺水解增加所衍生的乙醇胺的磷酸化。结果表明，EtnP生成增加与致癌作用的早期阶段相关。这一观察结果可能具有预后价值。
