具有稳定细胞色素P-450的大鼠肠道微粒体的分离及其对苯并（α）芘的代谢 - Suppr

Suppr

超能文献

The isolation of rat intestinal microsomes with stable cytochrome P-450 and their metabolism of benzo(alpha) pyrene.

作者信息

Stohs S J, Grafström R C, Burke M D, Moldéus P W, Orrenius S G

出版信息

Arch Biochem Biophys. 1976 Nov;177(1):105-16. doi: 10.1016/0003-9861(76)90420-3.

DOI:10.1016/0003-9861(76)90420-3

PMID:826220

Abstract

摘要

相似文献

The isolation of rat intestinal microsomes with stable cytochrome P-450 and their metabolism of benzo(alpha) pyrene.具有稳定细胞色素P-450的大鼠肠道微粒体的分离及其对苯并（α）芘的代谢

Arch Biochem Biophys. 1976 Nov;177(1):105-16. doi: 10.1016/0003-9861(76)90420-3.

Inhibition of benzo(a)pyrene and benzo(a)pyrene 7,8-dihydrodiol metabolism by benzo(a)pyrene quinones.苯并(a)芘醌对苯并(a)芘和苯并(a)芘7,8-二氢二醇代谢的抑制作用。

Cancer Res. 1979 Oct;39(10):4123-9.

Cytochrome P-450-linked activation of 3-hydroxybenzo(alpha)pyrene.细胞色素P-450介导的3-羟基苯并（α）芘活化作用。

Biochem Biophys Res Commun. 1975 Aug 4;65(3):894-900. doi: 10.1016/s0006-291x(75)80469-4.

Characteristics of microsomal reduction of benzo[a]pyrene 4,5-oxide.苯并[a]芘4,5-氧化物微粒体还原的特征。

Chem Biol Interact. 1982 Jul 1;40(3):345-56. doi: 10.1016/0009-2797(82)90157-0.

3-Methylcholanthrene does not induce in vitro xenobiotic metabolism in spiny lobster hepatopancreas, or affect in vivo disposition of benzo[a]pyrene.3-甲基胆蒽不会在多刺龙虾肝胰腺中诱导体外异生物质代谢，也不会影响苯并[a]芘的体内处置。

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1984;78(1):241-5. doi: 10.1016/0742-8413(84)90076-8.

Differential effects of disulfiram and diethyldithiocarbamate on small intestinal and liver microsomal benzo[a]pyrene metabolism.

Biochem Pharmacol. 1980 Jun 1;29(11):1517-23. doi: 10.1016/0006-2952(80)90602-4.

The mechanistic plurality of cytochrome P-450 and its biological ramifications.细胞色素P-450的作用机制多样性及其生物学影响

Xenobiotica. 1984 Jan-Feb;14(1-2):105-18. doi: 10.3109/00498258409151401.

The effect of phenobarbital, 3-methylcholanthrene, 3,4-benzpyrene, and pregnenolone-16 alpha-carbonitrile on microsomal heme oxygenase and splenic cytochrome P-450.苯巴比妥、3-甲基胆蒽、3,4-苯并芘和孕烯醇酮-16α-腈对微粒体血红素加氧酶和脾细胞色素P-450的影响

Arch Biochem Biophys. 1974 Jan;160(1):274-8. doi: 10.1016/s0003-9861(74)80034-2.

Metabolism of benzo[a]pyrene. Effect of 3-methylcholanthrene pretreatment on metabolism by microsomes from lungs of genetically "responsive" and "nonresponsive" mice.苯并[a]芘的代谢。3-甲基胆蒽预处理对来自基因“反应性”和“无反应性”小鼠肺微粒体代谢的影响。

Arch Biochem Biophys. 1977 Jan 15;178(1):256-63. doi: 10.1016/0003-9861(77)90190-4.

An improved method for preparing rat small intestine microsomal fractions for studying drug metabolism.

Anal Biochem. 1979 Feb;93(1):73-81.

引用本文的文献

Optimization of intestinal microsomal preparation in the rat: A systematic approach to assess the influence of various methodologies on metabolic activity and scaling factors.大鼠肠道微粒体制备的优化：评估各种方法对代谢活性和比例因子影响的系统方法。

Biopharm Drug Dispos. 2017 Apr;38(3):187-208. doi: 10.1002/bdd.2070.

Quantifying gut wall metabolism: methodology matters.量化肠壁代谢：方法很重要。

Biopharm Drug Dispos. 2017 Mar;38(2):155-160. doi: 10.1002/bdd.2062. Epub 2017 Feb 14.

Evaluation of memory enhancing clinically available standardized extract of Bacopa monniera on P-glycoprotein and cytochrome P450 3A in Sprague-Dawley rats.评价益智草药巴卡的临床可用标准化提取物对 Sprague-Dawley 大鼠 P-糖蛋白和细胞色素 P4503A 的影响。

PLoS One. 2013 Aug 28;8(8):e72517. doi: 10.1371/journal.pone.0072517. eCollection 2013.

Individual variation in first-pass metabolism.首过代谢的个体差异。

Clin Pharmacokinet. 1993 Oct;25(4):300-28. doi: 10.2165/00003088-199325040-00005.

Hydroxylation of dibutylnitrosamine in the human liver and intestinal microsomal fractions.

Arch Toxicol. 1986 Feb;58(3):196-8. doi: 10.1007/BF00340981.

Drug metabolism in rat colon: resolution of enzymatic constituents and characterization of activity.大鼠结肠中的药物代谢：酶成分的解析及活性表征

Mol Cell Biochem. 1987 May;75(1):51-60. doi: 10.1007/BF00231608.

Differential inhibition of biphenyl hydroxylation in perfused rat liver.灌注大鼠肝脏中对联苯羟基化的差异抑制作用

Naunyn Schmiedebergs Arch Pharmacol. 1978 Oct;304(3):297-301. doi: 10.1007/BF00507972.

Differential effects of antioxidants, steroids and other compounds on benzo(a)pyrene 3-hydroxylase activity in various tissues of rat.抗氧化剂、类固醇及其他化合物对大鼠不同组织中苯并(a)芘3-羟化酶活性的差异影响。

Br J Cancer. 1979 Jul;40(1):105-12. doi: 10.1038/bjc.1979.146.

Aldrin epoxidase in liver and small intestine of rat and Japanese quail.大鼠和日本鹌鹑肝脏及小肠中的艾氏剂环氧化酶

Bull Environ Contam Toxicol. 1979 Mar;21(4-5):498-501. doi: 10.1007/BF01685460.

Biotransformation of xenobiotics in human intestinal mucosa.外源性物质在人肠黏膜中的生物转化

Environ Health Perspect. 1979 Dec;33:71-8. doi: 10.1289/ehp.793371.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验