Chambers H F, Fournier M A
Department of Medicine, San Francisco General Hospital, CA 94110.
J Antimicrob Chemother. 1993 Sep;32(3):453-8. doi: 10.1093/jac/32.3.453.
The activity of cefoperazone with and without sulbactam was studied in vitro and in vivo against strains of methicillin-resistant and methicillin-susceptible Staphylococcus aureus. Cefoperazone with or without sulbactam was inactive in vitro against the methicillin-resistant strain and was bound by penicillin-binding protein 2a with an IC50 of 190 mg/L (the concentration that reduced radio-labelling with 3H-penicillin by 50%). Cefoperazone was hydrolysed by beta-lactamase in vitro but sulbactam improved cefoperazone activity in a rabbit model of aortic valve endocarditis caused by a beta-lactamase producing methicillin-susceptible strain.
研究了头孢哌酮在有或无舒巴坦情况下对耐甲氧西林和甲氧西林敏感金黄色葡萄球菌菌株的体外和体内活性。有或无舒巴坦的头孢哌酮在体外对耐甲氧西林菌株无活性，且与青霉素结合蛋白2a结合，IC50为190mg/L（使3H-青霉素放射性标记降低50%的浓度）。头孢哌酮在体外可被β-内酰胺酶水解，但在由产β-内酰胺酶的甲氧西林敏感菌株引起的主动脉瓣心内膜炎兔模型中，舒巴坦可提高头孢哌酮的活性。
