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Antimicrob Agents Chemother. 1995 May;39(5):1173-7. doi: 10.1128/AAC.39.5.1173.
2
Synergistic enhancement of in vitro antimicrobial activity of imipenem and cefazolin, cephalothin, cefotiam, cefamandole or cefoperazone in combination against methicillin-sensitive and -resistant Staphylococcus aureus.亚胺培南与头孢唑林、头孢噻吩、头孢替安、头孢孟多或头孢哌酮联合应用对甲氧西林敏感和耐药金黄色葡萄球菌体外抗菌活性的协同增强作用。
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In-vitro activity of imipenem combined with beta-lactam antibiotics for methicillin-resistant Staphylococcus aureus.亚胺培南联合β-内酰胺类抗生素对耐甲氧西林金黄色葡萄球菌的体外活性
J Antimicrob Chemother. 1991 Jun;27(6):809-15. doi: 10.1093/jac/27.6.809.
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[Antibacterial activity of imipenem in combination with ampicillin against methicillin-resistant strains of Staphylococcus aureus].亚胺培南与氨苄西林联合对耐甲氧西林金黄色葡萄球菌的抗菌活性
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Failure of routine susceptibility tests to detect imipenem resistance among strains of methicillin-resistant Staphylococcus aureus.常规药敏试验未能检测出耐甲氧西林金黄色葡萄球菌菌株对亚胺培南的耐药性。
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本文引用的文献

1
Efficacy of cefoperazone in combination with sulbactam in experimental Staphylococcus aureus endocarditis in rabbits.头孢哌酮联合舒巴坦治疗兔实验性金黄色葡萄球菌性心内膜炎的疗效
J Antimicrob Chemother. 1993 Sep;32(3):453-8. doi: 10.1093/jac/32.3.453.
2
Molecular aspects of methicillin resistance in Staphylococcus aureus.金黄色葡萄球菌对甲氧西林耐药的分子机制
J Antimicrob Chemother. 1994 Jan;33(1):7-24. doi: 10.1093/jac/33.1.7.
3
Synergism between aminoglycosides and cephalosporins with antipseudomonal activity: interaction index and killing curve method.具有抗假单胞菌活性的氨基糖苷类药物与头孢菌素之间的协同作用：相互作用指数和杀菌曲线法
Antimicrob Agents Chemother. 1982 Nov;22(5):743-52. doi: 10.1128/AAC.22.5.743.
4
Low-affinity penicillin-binding protein associated with beta-lactam resistance in Staphylococcus aureus.与金黄色葡萄球菌β-内酰胺耐药性相关的低亲和力青霉素结合蛋白。
J Bacteriol. 1984 May;158(2):513-6. doi: 10.1128/jb.158.2.513-516.1984.
5
Effect of NaCl and nafcillin on penicillin-binding protein 2a and heterogeneous expression of methicillin resistance in Staphylococcus aureus.氯化钠和萘夫西林对金黄色葡萄球菌青霉素结合蛋白2a及耐甲氧西林异质性表达的影响
Antimicrob Agents Chemother. 1987 Dec;31(12):1982-8. doi: 10.1128/AAC.31.12.1982.
6
Effects of temperature, NaCl, and methicillin on penicillin-binding proteins, growth, peptidoglycan synthesis, and autolysis in methicillin-resistant Staphylococcus aureus.温度、氯化钠和甲氧西林对耐甲氧西林金黄色葡萄球菌中青霉素结合蛋白、生长、肽聚糖合成及自溶的影响
Antimicrob Agents Chemother. 1987 Nov;31(11):1727-33. doi: 10.1128/AAC.31.11.1727.
7
Conversion of a homogeneously methicillin-resistant strain of Staphylococcus aureus to heterogeneous resistance by Tn551-mediated insertional inactivation.通过Tn551介导的插入失活将金黄色葡萄球菌的均匀耐甲氧西林菌株转化为异质性耐药。
Eur J Clin Microbiol. 1986 Dec;5(6):714-8. doi: 10.1007/BF02013311.
8
Binding of beta-lactam antibiotics to penicillin-binding proteins in methicillin-resistant Staphylococcus aureus.β-内酰胺类抗生素与耐甲氧西林金黄色葡萄球菌中青霉素结合蛋白的结合。
J Infect Dis. 1990 Jun;161(6):1170-6. doi: 10.1093/infdis/161.6.1170.
9
In-vitro activity of imipenem combined with beta-lactam antibiotics for methicillin-resistant Staphylococcus aureus.亚胺培南联合β-内酰胺类抗生素对耐甲氧西林金黄色葡萄球菌的体外活性
J Antimicrob Chemother. 1991 Jun;27(6):809-15. doi: 10.1093/jac/27.6.809.
10
In vitro synergistic activity between meropenem and other beta-lactams against methicillin-resistant Staphylococcus aureus.美罗培南与其他β-内酰胺类药物对耐甲氧西林金黄色葡萄球菌的体外协同活性。
Eur J Clin Microbiol Infect Dis. 1991 Feb;10(2):77-84. doi: 10.1007/BF01964412.

头孢哌酮与亚胺培南对耐甲氧西林金黄色葡萄球菌的浓度依赖性协同和拮抗作用。

Concentration-dependent synergy and antagonism between cefoperazone and imipenem against methicillin-resistant Staphylococcus aureus.

作者信息

Rand K H, Brown P

机构信息

Department of Pathology, University of Florida, Gainesville 32610, USA.

出版信息

Antimicrob Agents Chemother. 1995 May;39(5):1173-7. doi: 10.1128/AAC.39.5.1173.

DOI:10.1128/AAC.39.5.1173
PMID:7625809
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC162704/
Abstract

By the agar dilution checkerboard method, striking synergy between cefoperazone and imipenem was observed with 32 strains of methicillin-resistant Staphylococcus aureus (fractional inhibitory concentration indices, < or = 0.03 to 0.34; mean, 0.12 +/- 0.08). By the double-disk diffusion method, the synergy was confirmed, but about 60% of strains showed antagonism manifest by truncation of the zone of inhibition around cefoperazone. The mechanism may involve auxiliary factors distinct from those essential for the expression of methicillin resistance.

摘要

通过琼脂稀释棋盘法，在32株耐甲氧西林金黄色葡萄球菌中观察到头孢哌酮与亚胺培南之间有显著协同作用（部分抑菌浓度指数，≤0.03至0.34；平均值，0.12±0.08）。通过双纸片扩散法，协同作用得到证实，但约60%的菌株表现出拮抗作用，表现为头孢哌酮周围抑菌圈截断。其机制可能涉及与耐甲氧西林表达所必需的因素不同的辅助因子。