头孢哌酮与亚胺培南对耐甲氧西林金黄色葡萄球菌的浓度依赖性协同和拮抗作用。
Concentration-dependent synergy and antagonism between cefoperazone and imipenem against methicillin-resistant Staphylococcus aureus.
作者信息
Rand K H, Brown P
机构信息
Department of Pathology, University of Florida, Gainesville 32610, USA.
出版信息
Antimicrob Agents Chemother. 1995 May;39(5):1173-7. doi: 10.1128/AAC.39.5.1173.
Abstract
By the agar dilution checkerboard method, striking synergy between cefoperazone and imipenem was observed with 32 strains of methicillin-resistant Staphylococcus aureus (fractional inhibitory concentration indices, < or = 0.03 to 0.34; mean, 0.12 +/- 0.08). By the double-disk diffusion method, the synergy was confirmed, but about 60% of strains showed antagonism manifest by truncation of the zone of inhibition around cefoperazone. The mechanism may involve auxiliary factors distinct from those essential for the expression of methicillin resistance.
摘要
通过琼脂稀释棋盘法，在32株耐甲氧西林金黄色葡萄球菌中观察到头孢哌酮与亚胺培南之间有显著协同作用（部分抑菌浓度指数，≤0.03至0.34；平均值，0.12±0.08）。通过双纸片扩散法，协同作用得到证实，但约60%的菌株表现出拮抗作用，表现为头孢哌酮周围抑菌圈截断。其机制可能涉及与耐甲氧西林表达所必需的因素不同的辅助因子。
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本文引用的文献
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