Meldrum R D, Bloebaum R D, Dorr L D
San Francisco Orthopedic Residency Training Program, California 94117.
J Biomed Mater Res. 1993 Nov;27(11):1349-55. doi: 10.1002/jbm.820271102.
Although there are many studies which document high metal ion concentrations in clinically retrieved tissues surrounding total joint replacements, most investigations have remained cautious in their interpretation due to the artifactual influences of metal particulate. The possible contribution of polyethylene wear debris to artifactually high periprosthetic metal ion concentration readings has not been previously considered. This study documents the potential role of polyethylene particulate contamination in causing artifactually high metal concentration readings in tissues. The data showed metal ion contamination in the polyethylene was progressive at each stage of exposure to metal: from bar stock preparation, to manufacturing, to in vivo ambulation. The manufacturing and machining processes showed a statistically significant (P < or = .05) increase in metal ion concentrations in the nonarticulated acetabular inserts over bar stock. The results of this study demonstrate that periprosthetic tissue and synovial fluid metal ion concentration data must be interpreted with caution due to possible artifactual problems associated with metal ion contaminated polyethylene particulate.
尽管有许多研究记录了全关节置换周围临床取出组织中高金属离子浓度，但由于金属颗粒的人为影响，大多数研究在解释时仍持谨慎态度。聚乙烯磨损碎屑对假体周围金属离子浓度读数人为偏高的可能影响此前尚未得到考虑。本研究记录了聚乙烯颗粒污染在导致组织中金属浓度读数人为偏高方面的潜在作用。数据显示，聚乙烯在接触金属的每个阶段（从棒材制备、制造到体内行走）的金属离子污染都是渐进的。制造和加工过程显示，与棒材相比，未铰接髋臼内衬中的金属离子浓度有统计学显著升高（P≤0.05）。本研究结果表明，由于与金属离子污染的聚乙烯颗粒相关的可能人为问题，假体周围组织和滑液金属离子浓度数据的解释必须谨慎。
